In general, it is recommended that you work with a librarian to help you design comprehensive search strategies across a variety of databases. Writing a successful search strategy takes an intimate knowledge of bibliographic databases.
Using boolean logic is an important component of writing a search strategy. This can be tricky, because each database operates a little differently. However, some general rules of thumb are that:
Add the following lines to your search strategy with AND to filter for randomized controlled trials:
(randomized controlled trial [pt] OR controlled clinical trial [pt] OR randomized [tiab] OR placebo [tiab] OR drug therapy [sh] OR randomly [tiab] OR trial [tiab] OR groups [tiab])
TX allocat* random* OR (MH "Quantitative Studies") OR (MH "Placebos") OR TX placebo* OR TX random* allocat* OR (MH "Random Assignment") OR TX randomi* control* trial* OR TX ( (singl* n1 blind*) OR (singl* n1 mask*) ) OR TX ( (doubl* n1 blind*) OR (doubl* n1 mask*) ) OR TX ( (tripl* n1 blind*) OR (tripl* n1 mask*) ) OR TX ( (trebl* n1 blind*) OR (trebl* n1 mask*) ) OR TX clinic* n1 trial* OR PT Clinical trial OR (MH "Clinical Trials+")
Sources and more information:
Add the following lines to your search strategy to include only human studies and exclude animal studies (line numbers are examples only, line 8 = final search strategy before addition of human studies filter):
8 |
#3 AND #6 AND #7 |
9 |
Animals[Mesh] NOT Humans[Mesh] |
10 |
#8 NOT #9 |
8 |
#3 AND #6 AND #7 |
9 |
MH(Animals+ NOT Humans+) |
10 |
#8 NOT #9 |
8 |
#3 AND #6 AND #7 |
9 |
MeSH descriptor: [Animals] explode all trees |
10 |
MeSH descriptor: [Humans] explode all trees |
11 |
#9 NOT #10 |
12 |
#8 NOT #11 |